Sanofi's tolebrutinib drug delays progressive MS by 31% in trial

By Ludwig Burger

FRANKFURT (Reuters) -Sanofi said on Friday that its multiple sclerosis drug candidate was shown to delay worsening of a progressive form of the disease by 31%, as the French drugmaker eyes a request for approval later this year.

The company said earlier this month in a brief summary that the late-stage trial with the drug candidate tolebrutinib was successful. That mitigated a setback announced at the same time that trials on a more common relapsing form of the disease had failed.

Sanofi (NASDAQ:SNY ) is pursuing several opportunities in MS, a debilitating nerve disease, to offset revenue losses after the recent end of MS pill Aubagio's patent protection, part of a push to become a powerhouse in anti-inflammatory drugs.

CEO Paul Hudson (NYSE:HUD ) has made progress regaining investor confidence in the pharma pipeline since he unexpectedly abandoned 2025 margin targets last October to boost drug development spending.

Tolebrutinib, from the $3.7 billion takeover of Principia in 2020, belongs to a class of compounds known as Bruton's tyrosine kinase (BTK) inhibitors, which has also attracted Novartis (SIX:NOVN ) and Roche.

They are designed to selectively block the harmful autoimmune reaction behind MS for a more targeted approach than standard immunosuppressant drugs.



Investors however have been kept on edge over revenue prospects because of a possible link of BTK inhibitors to liver damage and uncertain efficacy.

Sanofi said frequent monitoring during trials had mitigated serious liver problems.

Source: Investing.com